I get a burning and itching sensation mostly at night around midnight either in my inner thighs or ankles or calves. I have been to a dermatiologist,neroulogist, general MD, allergist with no results. I do have ulcerative colitis which acts up in the fall and winter the same time the burning seems to act up as well. I don't know if there is a correlation. No topical ointments seem to help. If I put bags of ice on my legs that helps calm things down then I go back to bed. This has been going on for 2 years now. The first bout I had with it was when I traveled to Las Vegas it hit me one night very bad. I'm lost as what to do next.