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My husband has a problem with mucus in his throat. He can't seem to cough it up. He has had it for many months. At night when he lays down, he says he can feel it drain into his throat and it makes it difficult to breathe.

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this sounds like a heavy post nasal drip( excess mucous production), it can be caused by allergies and can be treated but does mean he needs to see his doctor.
hope this helps
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