This board seems very helpful. I've been encouraged to reach somebody if your stories. I have been on nose spray over the counter both Africa and four-way for over 30 years off and on.  I did kick it once, that went back to it  when I was going through a break up and doing lots of crying. I put back on it now for about a decade and most of the time, managing. 

This week I got a really bad cold, and the Afrin wasn't working so I went to the four way.  The four-way nose spray worked immediately and really well but it lasted a very short time – about an hour. After an hour, I could feel myself getting stuff to it within two hours I was totally blocked both sides . 

 I called my doctor today and ended up getting a prescription for prednisones on a tapering schedule which helped me once before. My question is this… How long should it take the prednisone to start working? It is now 10 pm.  I took 60 mg of prednisone at 4 PM. I have had to take The 4 way tonight .. about 7 so that I could sleep a little and eat something.  It has worn off now and I am totally blocked on both sides again . I thought I remembered prednisones working faster than this. I don't want to take anymore no spray tonight. I want to wait and see if this works but I'm wondering how long it should take to work. Does anyone have any information on that?