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Hi there,
I am not really sure if this swelling has to do anything with the Depo, but it is definitely a lymph node swelling. And lymph nodes are swollen only if the infection is presented near the lymph nodes. In your case I guess that you are having some infection in your leg or maybe in your lower abdomen or in pubic area. These swelling of the lymph nodes might not be serious. However if the infection is gone so will the swelling.
It is important to find the underlying reason of the inflammation in the body. Then you can begin the treatment with the right medication. What size is the lump? Is it painful when you touch it?
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