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my husband lost like 20lbs with out trying and he has a cold sore plus he's tired and not sleeping could it be thyroid,flu?

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This sounds very serious because losing weight is never without a reason except if you are trying to lose weight on purpose. 

How long does he have this symptoms? At first I would think it is a flue but you can't really know until you visit a doctor. 

Since it has been a while from your last visit and posting this question now I am curious to discover what has happen at the end?
Was it just flue or maybe something serious? 

Anyway I hope that you have resolved your problem and that your husband is just fine. Thank you in advance. 
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