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Diagnosis of overactive thyroid (Grave's disease) quickly leads to treatment with radioactive iodine to destroy the gland. Diagnosis of underactive thyroid (hypothyroidism) quickly leads to thyroid hormone replacement. But do these treatments really help?

If you think you have either hyperthyroidism or hypothyroidism, you need to see a doctor. Thyroid problems are not conditions you can treat on your own, and it's important to test, not guess, as thyroid expert Dr. Keith Ungar likes to say. Don't rely on just how you feel to measure your progress. Work out your treatment plan with your doctor.

But as you work out your thyroid treatment plan, be sure to ask your doctor these important questions:

Are you sure it's really a thyroid problem?

Both hypothyroidism and hyperthyroidism can be symptoms of other conditions. Hypothyroidism symptoms are not unusual in people who suffer sleep apnea, although it is the lack of sleep that is the problem. Chronic fatigue syndrome, mononucleosis, and systemic autoimmune diseases, as well as under-nutrition (as in Dylan's case), can result in the grinding fatigue, sluggishness, and weight gain that often gets people in to see their doctors.

Rarely, hyperthyroidism is caused by a tumor in the pituitary gland. In women, hyperthyroidism can be a complication of polycystic ovarian syndrome (PCOS). The condition can also occur during pregnancy, along with morning sickness. Users of cocaine sometimes develop short-term hyperthyroidism symptoms, and chronic anxiety, with disturbances in adrenal hormones, can cause temporary fluctuations in thyroid hormone. 

Are you measuring both T3 and T4? If you aren't, why not?

The thyroid makes large amounts of an inactive, storage form of thyroid hormone called T4. This hormone is converted a small amount at a time into the active form of thyroid hormone known as T3. In some people, the thyroid makes large amounts of T4, but isn't able to convert it into T3. In people who take natural thyroid hormone replacement, such as Armour Thyroid, their bodies are getting T3 from the medication so the thyroid quits making T4.

Don't worry about remembering the difference. Get your doctor to explain it to you. But if your doctor can't or won't explain T3 vs T4 measurements to you, it may be a good idea to see a different doctor.

Have you run tests for both anti-TPO (thyroid peroxidase) and anti-thyroglobulin antibodies?

Sometimes the underlying problem in a thyroid condition is an attack on the thyroid by the immune system. Sometimes doctors run dozens of lab tests without ever testing for the anti-TPO and anti-thyroglobulin antibodies that would indicate the problem is an overactive immune system rather than a fundamentally sick thyroid, which requires a different kind of treatment.

Have you ruled out euthyroid sick syndrome?

In euthyroid sick syndrome, the thyroid is healthy but some other organ is not, so the thyroid shuts down the production of thyroid hormone to conserve energy while that organ heals. The diagnosis of euthyroid sick syndrome requires more of the doctor's clinical experience than any particular lab test, but it is also a good indication that watchful waiting could be a good idea.

Is it possible I have subclinical hypothyroidism?

Sometimes thyroid hormone levels aren't high or low enough to diagnose disease, but you still feel lousy anyway. Your doctor won't give you thyroid hormone replacement therapy, but you may get guidance on appropriate nutritional supplementation to correct deficiencies in copper, zinc, and selenium (megadoses aren't necessary) and ongoing followup until you feel good again.

  • Boelaert K, Newby PR, Simmonds MJ, et al. Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. Am J Med. Feb 2010. 123(2):183.e1-9.
  • Jacobson EM, Tomer Y. The CD40, CTLA-4, thyroglobulin, TSH receptor, and PTPN22 gene quintet and its contribution to thyroid autoimmunity: back to the future. J Autoimmun. Mar-May 2007. 28(2-3):85-98.
  • Photo courtesy of cbgrfx123 by Flickr : www.flickr.com/photos/72005145@N00/4043535285/
  • Photo courtesy of World Bank Photo Collection by Flickr : www.flickr.com/photos/worldbank/8575329876/