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I have been on cymbulta for a few weeks and I had one glass of wine one night with dinner and it effected me quit badly. I don't suggest mixing alcohol with any antidepressants and the effects are dangerous and can cause depression to become worse to the point of becoming suicidal. This is my experience but from what Iv read about the drug its definitely not a drug that should be mixed with alcohol as it goes with most antidepressants one the market today. In hine sight we take antidepressants to counteracted the effects of depression so if we mix a depressant drug with the meds it can be desasterious. I'm hanging to go out with friends and have a few drinks as im only young but it just doesn't agree with most people on this type of medication. My suggestion would be weigh up the pros and cons of taking cymbulta but at the end of the day even if your not on antidepressants the effects of alcohol can still be quit detrimental to your mental health Giselle
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