Hi I'm Talia, 20 years old and have been on depo since 18. I just got off of depo about 7 months ago. as soon as the depo wore off I started getting the worst cystic acne. I've always had clear skin but now it's just red,inflamed and painful acne. So I finally went to the doctors and now I'm on the pill (loestrin). My acne has gotten a little bit better but it's only been one week. Im seriously frustrated and I despise depo as it has caused many other problems besides this. It feels like my acne will never go away.