I had a very bad infection from a surgery and was unable to smoke pot for a couple weeks.  After I got out of the hospital I started to smoke again.  Now, I have loved weed for over 20 years and never had an issue, but now I HATE the feeling of being high.  Even one tiny toke will make me anxious and uncomfortable.  being the committed smoker I am, I tried sativas, indicas, hybrids, dabs, edibles and vaping with similar results:  I feel disgusting when the effects kick in.  Can one's anatomy change so much through blood loss, infection, antibiotics and lack of food that the way our body processes cannabinoids completely change?