Hi, i am really struggling to find explanations for the explanation of Lower Motor Neuron Signs.
Fasciculations- i understand they occur pathologically due to muscle denervation causing reduced Ach in synaptoc cleft and up regulation of post synaptic nicotinic receptors. Ach binds to the receptors but there is not enough available to cause full muscle contractions, therefore fasciculations result.
Why, how does denervation lead to muscle atrophy?? Is it something to do with collagen deposition and fibrosis? Can anyone help please?
I also have the same problem understanding the pathogenesis of hypotonia. I understand muscle tone is dependent on the muscle spindle. But how/why does this lead to fibrosis?
Any help is much appreciated,
Nicky
Fasciculations- i understand they occur pathologically due to muscle denervation causing reduced Ach in synaptoc cleft and up regulation of post synaptic nicotinic receptors. Ach binds to the receptors but there is not enough available to cause full muscle contractions, therefore fasciculations result.
Why, how does denervation lead to muscle atrophy?? Is it something to do with collagen deposition and fibrosis? Can anyone help please?
I also have the same problem understanding the pathogenesis of hypotonia. I understand muscle tone is dependent on the muscle spindle. But how/why does this lead to fibrosis?
Any help is much appreciated,
Nicky