I have used every medication known to man for my Psoriasis, including Methotrexate. It helped in the beginning, but doesn't any more. This medicine is very serious. It's used to treat Cancer patients also. You need your blood checked every month to make sure it is not doing any damage to your internal organs. Now I am trying a new therapy that is said to work. I guess we'll see. I read that Psoriasis is caused from toxins in your body. I am using a Detox to cleanse my whole system and taking Omega3 pills. At this point, I am willing to try anything!!