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The phrase "Not everything that shines is gold" also applies to scientific research, unfortunately. People believe that all scientific knowledge is true, but scientific fraud exists and it is more common than you would imagine.

The quest of a scientist

The search of truth is the foundation of the professional development of a researcher, either on matters of galaxies, stars, new planets and physical forces, or matters of the human body and diseases. Unfortunately, on the road for the search of truth, some researchers may feel tempted to follow another path, which ends in scientific misconduct. Yes, it sound contradictory, but this is mainly what has been going on since the beginnings of scientific research.

A case of scientific fraud 

Just a few months back, a research group working at the RIKEN Center for Developmental Biology, based in Japan, published the results of years of experiments that seemed to be ground-breaking: they were able to turn mature cells into stem cells by using a very simple chemical procedure.

Some of you may not be aware of stem cell research, but it is a big deal.

Stem cells are cells that are not specialized and as such, they can be turn into different cell types, from a liver cell to a heart cell.

The problem with stem cells is that they have to be obtained from human embryos and this is a very difficult issue to address, ethically and technically speaking. One of the alternatives for this situation is to develop a technique that allows scientists to reverse the maturation process of a cell and convert already mature cells into stem cells. Mature cells would be easier to obtain and their use wouldn't cause as many ethical issues as stem cells work do. The impact of this would be huge of course, especially because stem cells could be used to treat diseases where cell death or lose of function is the main problem.

Scientists could eventually replace damaged cells with stem cells originated from mature ones. 

Reproducibility issues

The research group published all their data in one of the most important, if not the most important, journal in Natural Sciences: Nature.  The problem started when other groups tried to reproduce the same experiments in their own labs and did not succeed. Did this mean that the results were made up? That everything that was published in one of the top journals, was a lie? 

The RIKEN Institute quickly took action into this matter and eventually, the investigation reported that the main researcher was guilty of scientific misconduct, since many of the results that she reported were false.

These type of situations happen more often than you would imagine. You would wonder then, why would researcher fall into scientific misconduct? Wouldn't it mean to risk, not just years of work, but also your reputation and that of the whole research group? I believe that there is absolutely no valid reason that can excuse the modification or invention of experimental data, however, I can also think of many reasons why Dr. Obokata, the leader of the research team at the RIKEN Institute, and other many more researchers before her (because there are many reported cases of scientific fraud before this one), could commit scientific fraud. 

Scientific Misconduct And What Could Lead To It

First of all, the pressure that scientists have to publish a certain number of papers in top journals is very intense. There is a very famous saying in the research area that goes like this: “Publish or perish”, and it is absolutely true.

When applying for a job, a place at a University or a research grant from the government or a foundation, your track of published papers is basically one of the most important things in the CV. This is how you are evaluated as a scientist, basically. 

When you send a paper with your experimental results, it goes through a very long process, which can last as long as a year or so, of revisions and modifications. Then, it is either accepted for publication, or rejected.

Putting this into numbers, so you can have a broad idea, from all the papers that are submitted in a certain journal, only 10 to 15% of them will be accepted for publication.

This is quite a stressful percentage: ff you don’t publish, your are doomed, basically.

Knowledge means money, also

The money could also play an important role in the decision of scientists to falsify or modify experimental data. You may not know, but in order to do research, you need money that comes either from the government or from research funding institutions, such as charities. To get a grant for a research project you have to compete with thousands of applicants and the selections process is quite tough. It has to be, because after all, you are given a considerable amount of money to shed light into a specific issue that is affecting people’s lives.

Maybe this is why scientific misconduct is mostly seen in areas related to Biomedical research and the search for treatments and cures for diseases

Science is a human activity after all

Going back to Dr. Obokata's case, I may be over analyzing the situation and in the end, she may have falsified her results just to get published in a very important journal and make history as a researcher with her new discovery. This is also possible. Who wouldn’t like to make a great discovery and save humanity? I would, for sure.

My main point in telling you about Dr. Obokata's case is mainly to make you realize that, even when most people think otherwise, science is not perfect.

In the end, it is the result of human activity, and as such, it is subjected to human errors, whether they are committed by mistake or deliberately. As a scientist, I was taught to question everything, even my own negative or positive experimental results.  

This is also a basic premise in research: we shouldn’t believe everything we read; there is always some room for discussion in order to identify weak points in our research and make it better.

I don’t intend to make you doubt from everything that the scientific community publishes, but just to make you notice that we are also humans and are entitled to make mistakes. As general public, we have to be able to judge the information that comes into our houses, through any type of media. This is an excellent exercise and it would certainly help in increasing the quality of whatever is published, not only in the scientific area, but in every other one that exists. 

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