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Orbital pseudotumors is a benign condition that is roughly about 10 percent of all masses on the surface of your eye. Scientists have yet to determine what the underlying cause of this is and the presentation of the disease is highly dependent on the individual. Some patients will present with just a palpable mass but in more severe cases, it is possible for patients to have 

  • a swollen eye, 
  • discharge from your eye, 
  • decreased motility of the eye 
  • and even decreased vision. 

In about a quarter of these cases, both eyes can also be involved. 

These are a relatively common lesion and due to the unknown origin of what causes them, treatment options can be complicated. In some cases, the condition will self-resolve and no therapy will be needed at all. Unfortunately, this is only a small minority of patients so a more aggressive treatment approach will have to be used. The standard first-line therapy for patients with this condition includes oral corticosteroids and about 80 percent of patients have a complete resolution of symptoms after this round of medications. 

Unfortunately, about 50 percent of these cases will have a relapse of their symptoms and then treatment protocols become more ambiguous. A doctor could decide to try around round of oral corticosteroids but these are strong and power medications that you do not want to get used to. They can lead to numerous side effects like a lower immune system, severe weight gain and skin changes so it is better to avoid long-term dependence on these types of medications. 

An alternative secondary option that patients could also benefit from would be trying low-dose radiotherapy, cytotoxic chemotherapy, or immunosuppresive agents. All have similar risks but low-dose radiotherapy seems to have the most benefit in long-term studies. 

The last option that could be possible would be to have some type of surgical intervention to have the lesion removed. There is no guarantee that the lesion will not return but at least you will have a period of symptom-free life before this pseudotumor potentially returns. [1]

This is a condition that can be associated with autoimmune disorders so while you are seeking treatment options to correct your vision, make sure you visit your local Rheumatology Clinic to get tested for undiagnosed autoimmune conditions that could cause this eye condition. Conditions like SLE (Lupus), rheumatoid arthritis (RA) and vasculitis disorders are some of the more likely autoimmune diseases that you have to watch out for. 

Because of this connection with potential connect with autoimmune diseases, an emerging group of treatment options include similar treatments that are used in patients who have diagnosed autoimmune diseases. These include the increased use of antimetabolites, alkylating agents, cytotoxic agents and other immunosuppressive agents. [2] These medications come with their own panel of side effects but are much less intimidating to patients in comparison to the possibility of having radio- or chemotherapy. 

Your best course of action is to go to your local Ophthalmologist and begin treatment as soon as you notice these nodules on your eye in order to have the best possible response. 

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