What can you tell me about pharmacodynamics and clinical effects of accupril? I am taking Accupil30 mg daily for hypertension.
Administration of 10 to 80 mg of Accupril to patients with hypertension results in a reduction of sitting and standing blood pressure to about the same extent with minimal heart rate, symptomatic postural hypotension is infrequent although it can occur in patients who are salt-and/or volume-depleted. Antihypertensive activity commences within 1 hour with peak effects usually achieved by 2 to 4 hours after dosing but during chronic therapy, most of the blood pressure lowering effect of a given dose is obtained in 1-2 weeks.Doses of 40-80 mg were somewhat more effective at trough than 10-20 mg, and twice daily dosing tended to give a somewhat lower trough blood pressure than once daily ( dosing with the same total dose ) and the antihypertensive effect of ACCUPRIL continues during long-term therapy, with no evidence of loss of effectiveness.