Improved Cardiac Electrical Stability in Exercised Myocardial Infarct Rats with Left Ventricular Hypertrophy
Authors:
H. Dor-Haim1, C. Lotan1, M. Horowitz1, M. Swissa2, 1Hadassah Hebrew University - Jerusalem - Israel, 2Kaplan Medical Center - Rehovot - Israel,
Topic(s):
Mechanism (Basic Science in Arrhythmias)
Citation:
Europace Journal ( 2009 ) 11 ( S6 ), Abstract 185
Background: Aerobic training reduces the occurrence of sudden cardiac death, in patients with CHD. We hypothesized that prolonged training will alter heart substrate for arrhythmia, thus increase electrophysiological stability in myocardial infarct (MI) heart model.
Methods: Adult rats (n=30) were studied for 8 weeks. The first group (n=6) underwent LAD ligation to form MI and then trained on a treadmill for 8 weeks (TMI). A second intact group (n=8) was trained, as well, for 8 weeks (ITT). A third group (n=8) underwent LAD ligation was investigated under sedentary conditions (SMI) and a forth sham operated group (n=16) was served as sedentary control (SCN). Eventually, EPS study was performed on the isolated Langendorff perfusion-system.
Results: TMI Isolated trained hearts showed 3-fold improvement in their tolerance to the induction of ventricular fibrillation (VF) in comparison to SMI. ITT, TMI and SMI hearts were significantly hypertrophied compared to SCN (15%, 18% and 20% increase respectively P
Conclusion: This study demonstrates the electrophysiological protective effect of aerobic training on MI heart model. Training has normalized the MI adverse effect on cardiac electrophysiology, despite ventricular hyperthrophy and structural remodeling of the heart. The improvement may be related to enhanced cardiac conductance and improved refractoriness induced by aerobic training.
See a cardiologist who specializes in Arrhythmia disorders ASAP!
Seeing an Electrophysiologist along with a Cardiologist is a good fit for anyone with a arrythymia disorder - I am going through this right now as well. In a couple of days I am going through a Catheter Ablation to slow down my fast heartrate as medications and exercise have not worked with me to slow it down as well as the diet maybe because I am a Celiac? I will post back with results on how I feel after the ablation with my heart and how it affects my body and my daily living.
I went through a couple of Cardiologist's before I found the one that was the right fit for me and willing to try to find the answer while consulting with the Electrophysiologist. Make sure to ask for a 2nd opinion, it's OK and your right as a patient. Also, as much as you are able to, keep up your exercise it is sooo important for your heart and health keeping it at a manageable level.
Good luck all!
Hello friends!
I am 27. It was in October of 2011 that I started feeling a 'skipped heart beet' feeling. Gradually, within a month, it magnified and got to the proportion of Sinus Arythmia (after a Holter Monitoring). I then started taking anti arthymic medications and was getting back on track gradually after 3 months. Then, I discontinued the Med. after Doctors suggestions as these medication have a long term side effect on your body. But, soon within a year, the heart beat were fluctuating (slow-45, high-130), skipping and fluttering. I again went to the Best Electro.Doc. in Delhi. I was then suggested to undergo Ablation. I was petrified, even with the thought of it. I did not tell my parents or anybody of this finding. The condition became so worse that, I was breathless even on walking some steps, leave aside climbing stairs. I thought that I was about to die. But I had trust in myself and beleived that I could not die as I still had Purpose to my life. I than gradually, started with some Yoga postures along with mild walk. I must confess that it took me immense amount of perseverance and faith in myself and the formless God. Then, the next month I started walking on treadmill and now I run for 2 miles. From a condition where I could not have even walked I can now run miles. The Arterial flutterence and arythmias are all gone.
P.S: I have read all the stuf on blogs, and some people do have actual solutions to the heart condition. But, rarely did I see somebody geting completely rid of this condition.
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