at first i didnt think much of it, then one day i heard on t.v  that its a possible sighn of brain tomors. i have done a little more research and found out that alcohol,or drug abuse is a large cause of the problem. me being a former opiate addict(one year clean this month) i think explanes it for me,but being clean now and with no other habits shouldnt my pupils go back to normal at some point??? also on an other note these cases show very little cases where the condition is fatal,and unless your pupils changed when you started feeling very ill,having breathing problems,migranes,or heart/chest pain,i wouldnt loose to much sleep over it. i almost forgot bad circulation contributes also.