In Sept 2013 Doctors found a gene called PAX5 that is hereditary. This study was for ALL. So more research is under way at this time for CLL' CML' AML and others. So the puzzle is coming together. Do alittle research on PAX5 gene this was published worldwide. Good Luck. I made it through CML my heart goes out to everyone going through this.
I'm very glad you made it through CML. My story is my sister was just diagnosed with CML and was devastated. She's only 38. No history of leukemia only breast cancer in my mom. Who's a survivor.
Leukemia has the possibility of developing during many stages of blood cell development. Since all blood cells originate in the bone marrow from stem cells, this is the first place that we logically look to narrow down the cancer's origin. A genetic cause is what a large number of people think of first. But just know that there are environmental factors that can cause a person with a perfectly healthy genetic blood cell code to develop a problem in the stem cells residing in the bone marrow. For example, some people have been exposed to carcinogens (like agent orange or formaldehyde). The method and severity of their exposure to the compound can cause stem cells in their bone marrow to become damaged. In turn, their original genetic make up in one or more stem cells becomes altered and now these stem cells begin to produce "rogue" or cancer cells. This is a generalization, however it explains how leukemia can be caused by something other than a persons original genetic make up that was given to them by their parents.
May I ask what were the signs of leukemia for her in the beginning?
I believe leukemia is an EPIGENETIC disease. Epigenetics is the study of how genes get switched on and off, by environmental factors or chemical reactions within an organism. Our genes don't express themselves constantly through life, they get switched on and off. One thing that can contribute to leukemia is when oncogenes (cancer-causing) get switched into an "on" position and can't switch off. For instance, in Philadelphia chromosome positive leukemia (Ph+ ALL, and CML) tyrosine kinase gets switched "on" and won't switch back off - this helps the leukemia cells to proliferate out of control. The newest drugs for Ph+ leukemia are designed to inhibit tyrosine kinase and flip the switch "off" - those drugs aren't really killing the cancer cells directly. The way carcinogenic environmental factors interact with a person's genetics causes leukemia - I am convinced of it.
Certainly there are environmental factors (radiation exposure, benzene, exposure to some viruses, previous chemotherapy, cigarettes, higher BMI) that are known to contribute to leukemia. There isn't a gene that causes leukemia directly (not found yet) - not in the way that some diseases are strictly inherited/genetic... but there must be genetic differences that make certain people far more vulnerable to develop leukemia from exposure to environmental factors. The answer will most likely be found by the field of Epigenetics, as we learn more about the interactions between gene expression and our environment/chemical exposures.
In other words, leukemia FOR SURE has multi-factor, complex causes. Saying it is not hereditary means it's not directly caused by inherited genes (like Dwarfism is). That doesn't mean there aren't genetic factors involved, and there have to be genetic variations within humans that make some naturally more or less resistant to leukemia-contributing exposures.
Honey I can honestly feel and experience your anxiety with you. I am soooo sorry. although the first thing that would come to my mind is to forget my current symptoms and pretend like everything's rosey ..Id have to be strong..please get checked out.. is there anyone who can help you get to a doctor? I know costs can be expensive but i had a dream..or nightmare about this the other night. I woke up with the conclusion (just my own opinion for myself) that it would be better to be safe and know and even receive treatment for a longer life then wait one more day and perhaps miss the window to recovery. I am 34 and I have a 15 year old son 13 year old daughter and 2 year old with my fiancé. My grandfather died in his 50's while I was young. I think he fought for a few months maybe more.. If I was your mom id say LETS GET U CHeCKED OUT!! Xo good luck huny n Please be good to yourself.
My brother had ALL as a child and at that time there was no cure. Over time and much study trials he was clinically cured of his childhood leukemia, but now my own son is having swollen lymphnodes in his posterior neck with no other symptoms except stomach aches that he complains of occiasionally as well as a temperature as of late, but it has subsided. His doctor checked him out and thought maybe it was a virus, but why are his lympnodes still extremely large and won't go down. Should I be worried or seek another opinion? At least ask them to run a blood panel
Look up benzene chemical.. omdiet soda ? Cover up Also near coal mines and wells
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My husband died a year and half ago after undergoing a bone marrow transplant for C.L.L. He had mutiple other issues including kidney cancer. At his last check up he was given less than 6 months to live. He died 2 months later. He wasn't the only one in his family with leukemia however. His oldest sister had died a few years prior to his diagnosis. She also had C.L.L. And when he originally went for his bone marrow transplant his youngest sister was asked to be a donor. Upon completion of her blood work it was determined that she also had leukemia. His oldest brother survived thro I'd cancer. Is it heredity? I'm not positive in this case it was. The family grew up in endicott, near I.B.M., an area deemed the toxic plume. The chances of 3 siblings getting leukemia we were told are astronomical. Am I worried for my children and grand child? Absolutely. I'm praying that all works out for you. God bless.
My father had AML and then I was diagnosed with it too.
I'm afraid I will get cancer because my mom had got it an out of all my siblings me an my oldest brother look like my mom
I've always wondered about this. I'm an ALL survivor and my dad passed away from AML 10 years after I was first diagnosed. I worry for my future children as my fiance's mother is also a leukemia survivor.
You are the first person that I've found that has had a similar experience to me. My father suddenly became ill & we called for an ambulance. It wasn't until we were in the hospital that we found out he had acute myeloid leukaemia & had septic shock. 26hrs later he passed away. It's only been 2 weeks & I'm struggling to deal with it. My mom is worried it's hereditary.
how is she now?
i hope she is doing great
i hope she is doing great
My sister died of AML at 52 years old. My mom died of AML this year. I really do not care what
the doctors say - this is hereditary. I do not understand, with all multiple leukemia deaths within families, why this is not considered hereditary. I just can't believe it.
the doctors say - this is hereditary. I do not understand, with all multiple leukemia deaths within families, why this is not considered hereditary. I just can't believe it.