Hi, my nephew was treated with cytotoxic drugs, because he suffers from hematologic malignancy. He started having fever and abdominal pain, and the doctors suspected on typhlitis. What is this condition?
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Typhlitis is a condition when a neutropenic patient after cytotoxic hemotherapy has fever and right-lower-quadrant tenderness. It is an inflammation or necrosis of the cecum, appendix, and ileum. It is also referred as neutropenic colitis, a necrotizing colitis or ileocecal syndrome. This condition can be a result of overgrowth of clostridia in granulocytopenic patients. This process first appear as mucosal disruption. Then it leads to secondary intramural infection and subsequent edema and wall thickening. One of the most common symptoms is bloody diarrhea. Beside that, the symptoms are abdominal distention and nausea/vomiting.
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