I have been on YAZ for about a year. I had PMS, very bad cramps for weeks at a time and my face was breaking out in my 30's. It started working almost right away. My PMS is almost non-existant and my face cleared up and looks great! The only down side I have faced is about a 15 lb. weight gain. I would rather have that weight than the PMS! I would try it if you have really bad PMS and want acne to clear up. :-)