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Doctors have known for a very long time that celiac disease sometimes causes symptoms outside the digestive tract. An especially nasty form of skin inflammation known as herpetiform (herpes-like) dermatitis is caused by reactions to gluten, and many people who have celiac disease develop painful neuropathy (nerve deterioration) and ataxia (loss of muscle control).

However, more and more doctors are treating patients who have these symptoms of celiac disease outside the digestive tract without obvious evidence of disease in the digestive tract.
Curing Some Cases of Dementia, Epilepsy
Investigators at the Mayo Clinic in Minnesota believe that celiac disease may activate antibodies in the digestive system that travel through the bloodstream to the brain. Their understanding of the disease process remains theoretical, but they have been able to cure many cases of autoimmune epilepsy and age-related cognitive decline.
The Mayo Clinic doctors use a three-step treatment program to correct autoimmune disease of the brain.
- Destructive antibodies are filtered out of the blood through a process called plasmaphoresis.
- Patients are given steroids to suppress their own overactive immune systems.
- Then patients are given transfusions of immunoglobulin G, slow acting immune agents, from healthy patients to regulate their own immune systems and to help protect them from infections.
Not Every Case of Brain-Related Disease Is Caused by Gluten Sensitivity
In 2013, the Mayo Clinic tested for antibodies in 140,000 patients who had various symptoms of brain disease. The overwhelming majority of those tested did not have antibodies for autoimmune disease. Only about 1 in 10 people who has seizures, schizophrenia, migraine headaches, or muscle weakness disorders has a condition driven by gluten sensitivity, but for those 1 in 10, treatment can be life-changing.
How can you find out whether gluten sensitivity is causing your symptoms? Tests for the antibodies associated with the disease can be run from a saliva sample. You don't even have to have blood drawn. Most health insurance policies in the US cover this kind of testing in full, no copay required, but if you do not have health insurance or you have not met your deductibles for the year, most states (except New York) allow you to arrange for your own celiac disease antibody testing.
Researchers believe that thousands of people may be locked away in nursing homes and psychiatric treatment facilities who could return to normal lives if they were treated for celiac disease.
See Also: Autism - Should You Try a Casein and Gluten Free Diet for Your Child?
Elderly people assumed to have Alzheimer's disease or vascular dementia have been able to go back to their own homes when they have received the care they need. Many more have experienced significant improvement but not complete remission from their symptoms when they eliminated grains in their diets.
There's no need to go gluten-free if you don't have any symptoms, but if you do have symptoms that don't respond to medication, why not get tested? The test is simple, reliable, and relatively inexpensive about $100 if you have to pay for it yourself, free under most insurance plans, and you may be able to start improving right away.
- Genuis S, Bouchard T. Celiac disease presenting as autism. Journal Of Child Neurology [serial online]. January 2010. 25(1):114-119.
- Margutti P, Delunardo F, Ortona E. Autoantibodies Associated with Psychiatric Disorders. Current Neurovascular Research. January 2006. 3: 149-157.
- Photo courtesy of LearningLark by Flickr: www.flickr.com/photos/44282411@N04/7610164322
- Photo courtesy of Parker Knight by Flickr: www.flickr.com/photos/rocketboom/5715404419
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