I need to know if sore nipples is a side effort of Depakoke ER. I started taking this brand about two weeks ago and about a week ago my nipples have started getting really sore to the touch. As if they are preparing to get ready to nurse. I have an IUD (birth control - just as effective as having your tubes tied). So, the odds of me being pregnant are slim to none. As far as my period causing it. Well, I only have a period every six to seven months and it's not time for that to occur. Thanks for any and all comments.