I am currently taking Requip Xl which is very effective for my RLS. I am also coming off Cymbalta 120mg. daily. I'm having horriable withdrawls from the Cymbalta even though I'm following Dr'.s recommendations about coming off the Cymbalta. I'm wondering if the Requip XL will do the same if I ever have to come off it. I know they both interact with the brain nerves...