:? I have rheumatoid arthritis and a liver problem so my doctor had to put me on Oxycontin for joint pain a year and a half ago. I have gotten very tolerant to it. I take 480 mgs. a day. The thing of it is that I could tolerate a lot more than that. I do not get euphoria on it anymore and I am worried that if I was to get something like cancer it would take an enormous amount of it to help me. I don't know if there is anything I can do about it though. I will have to bring it up with my doctor I guess