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I was on Remeron in 1997-'98.  The first couple of times I smoked marijuana after starting Remeron, I had panic attacks, but the panic attacks eventually went away.  However, they were replaced by a physical feeling of alternating pressure and lack of pressure, like my veins were inflating and deflating constantly.  At first, it went away after a few days, but after smoking weed occasionally and taking Remeron consistently for six or eight months,, it only got worse to the point where I had the symptoms 24 hours a day.  It got so bad, I had to completely avoid caffeine and decongestants too.  So, I stopped the Remeron, but the symptoms NEVER went away.  I haven't smoked weed in 10 years, I don't drink alcohol or coffee at all, but the symptoms, 16 years later are still there.  I have seen numerous doctors, and the only diagnosis I have ever recieved is labile dysautonomia. 

My advice is: if you're going to smoke weed, don't take Remeron!  There are other antidepressants that don't react with marijuana so bad, like Prozac or Zoloft, though they may make you lazier than the average pot smoker.  But at least they won't give you panic attacks and a lifelong circulatory disorder.

In retrospect, I would have been healthier today if I threw out the Remeron and just smoked pot when I was depressed.

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I've had the same experience. I've smoked weed for years and ever since being placed on Remeron I have the most intense panic attacks every single time I smoke. It's terrible. They do not mix. Guess which one I'm dropping? (Hint, it's not the plant. :P)
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I took a 15mg mirtazopine and smoked the next day. It landed me in the hospital because I thought I was having a heart attack. My pb was 165 110 and I lost feeling in my arms. I've smoked everyday for four years and this only happened when I smoked with this stuff. Why the f**k did this happen!
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Lol u must of hit some loud
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You have experienced what many of us have to deal with daily, its a real disorder and I hate it.
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when my psychiatrist was perscribing me remeron she told me not to smoke anything on it, so naturally I was like okay yeah whatever. but whenever I smoked I would always get these waves of fatigue in which I felt so faint, dehydrated and overwhelmingly high where it was like a super trippy high even if I only smoked the smallest amount. I would love to know why this happens
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can we stay in touch. I'm mark. Just started yesterday on 30mg. Took one tonight also but feel like, after reading what you wrote, that I should have skipped tonight because it's 2:30 and I have to get up at 6:45am, and I feel absolutely terrific, so terrific in fact that I told my son and my wife that felt a little like Travolta in Phenomena when he had a tumor and from ordinary became a genius. It's not the genius I felt, though clarity y is party of it, as well as loss of forgetfulness and spacing out, but the cloud of depression that just make me think life is terrible was lifted. I don't know if it's going to be gone tomorrow, it's scary thinking pessimistic like that but you know, when most people, I guess, wake up every day moderately to super happy, I was the opposite. I've read so many people complain about remeron that want to get off and suffer withdrawals and it's just awful reading, but I don't want to believe that this drug can't help me forever and I don't want to believe that something bad will befall me at some point in the treatment. So i read your thing and I'm like "yes!!" so I don't know if I should give you my email to correspond with or what because I don't know if I'll be able to find this page again.
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I take 30mg of remeron per day and i've smoked cannabis for about 10 years and i can say the same thing has been happening to me since i started taking it. Crazy panick attacks, heart racing, sweating, thinking im gonna die lasting anywhere from 20 minutes to an hour after i smoke a small bowl. Not fun and kinda scares me honestly so i have stopped smoking while i remain on it. Hope it gets better man

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I’m on remeron and I smoke every day. There is nothing wrong with it. It just effects everyone differently. I was smoking everyday for at least 2 years before the meds so I don’t know it that has anything to do with it
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Hi there,

I realize this post was made 13 years ago, however if anyone like me is revisiting this in 2021 i though I’d let you know my experience of the weed and remeron interaction.

I was a daily smoker for years, and I mean years. Not once did I experience an anxious high or weed panic attack. As soon as I started my higher dose of remeron, my highs and were changed forever. Couldn’t get high with out feeling like my heart was gonna pound out of my chest. People often say these too don’t have an interaction, but I firmly believe they do.
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Hi there,

I realize this post was made 13 years ago, however if anyone like me is revisiting this in 2021 i though I’d let you know my experience of the weed and remeron interaction.

I was a daily smoker for years, and I mean years. Not once did I experience an anxious high or weed panic attack. As soon as I started my higher dose of remeron, my highs and were changed forever. Couldn’t get high with out feeling like my heart was gonna pound out of my chest. People often say these too don’t have an interaction, but I firmly believe they do.
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Thank you for not making me feel crazy. Went from being a daily smoker to having panic attacks whenever I smoked with Remeron.
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Starting Remeron after using Parnate (MAO) 25 years for depression. Smoke marijuana during my weaning off Parnate. How man days do you recommend waiting since last I use of marijuana before starting Remeron?
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I had this happen but it was from oversmoking. The intense paranoia and fear and heart attack thought lasted for about 3 hours for me. I dont do Remeron but thought that sharing this might help. Mind over matter when the oversmoking happens, that, eat and take some CBD.
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