Tramadol and Flexeril at the same time????

Be careful! I had a co-worker taking 3 tramadol at a time and passed away! He was 43 and fairly good health! He also doing it for years because of a bad back! FYI

These blogs dont settle well with me. I just read up on this combo and it is clearly not a great idea. However on another forum focused on the same exact topic one writer told the individual with the question that it is perfectly safe and encouraged the combo. This could potentially be a fatal mistake and to be told something so wrecklessly like that I think renders any suggestions on pages like this unreliable. To be perfectly honest there should be a color code system for professional responders and non professional. For example doctors respond in blue and non medical professionals in red. Either way I just wanted to report this to anyone who may be looking to pages like this for answers. Our loved ones lives are the risk here and nobody should take any advice from an unlicensed blog participant.

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I call b's cause I was just prescribed both and was instructed to take both

It is a Opiate but its made in a lab where as Hydracodone etc is grown naturally or derived from a opiate grown naturally as my doctor explained it to me.

Tramadol is along the same lines as Hydracodone and its often coupled with Cyclo or another muscle relaxer. Its just not as strong as Hydracodone.

Every person reacts differently. I was written scripts for 100mg of Ultram 4 times a day with 30mg of flexible night. I took them both together for several years and never had any serious issues.

My doctor gave me both

Holy sh*t that is way too much..

"Hydracodone" (I assume you mean hydrocodone) is not grown naturally: it is synthesized from codeine, which along with morphine, are the primary active components of opium poppies. Naturally occurring mu-opioid agonists are called opiates, and synthetic ones (like tramadol, heroin, hydromorphone, meperidine, fentanyl, and most of them) are called opioids to differentiate between the two.

Tramadol itself is actually a weak opioid and affects a number of other pathways in the brain, such as serotonin, but its primary metabolite, o-desmethyltramadol, is a much stronger opioid. Some people (like me) don't metabolize tramadol well due to genetically having a less effective form of the enzyme responsible for the metabolization, i.e. CYP450-2D6, so it does very little for us, even at high doses. (I have taken up to 500 mg of tramadol with almost no pain relief whatsoever.)

Flexeril (cyclobenzaprine) is structurally related to an older family of antidepressants called tricyclics, which also works on the serotonin syndrome.

When you combine drugs that work on serotonin, especially at high dosages, you put yourself at risk of an extremely unpleasant and potentially fatal condition called "serotonin syndrome."

Tramadol is also well-known for lowering the seizure threshold, i.e. it makes you more prone to seizures. This risk can be mitigated by taking drugs that tend to reduce the likelihood of seizures, such as benzodiazepines (think Valium, Xanax, Ativan), but mixing these together can be very risky for some people, since both tramadol and benzodiazepines suppress the central nervous system: thus, they can slow your breathing to levels that are dangerous and can result in death.

Cyclobenzaprine has an extremely long half-life of approximately 18 hours (i.e. after 18 hours, half the amount of the drug that you took is still in your system, and 18 hours after that, a quarter of the drug you took is still in your system). Thus, if you have taken a high dose of cyclobenzaprine, you should wait several days before taking tramadol. (On the other hand, tramadol has a short half-life of six hours, so you can probably take cyclobenzaprine fine the next day.)

At low doses, for most people, it is probably safe to mix cyclobenzaprine and tramadol, but if you are using high doses (e.g. more than 10 mg cyclobenzaprine and more than 100 mg tramadol), you could be asking for trouble.

I am amazed by how little people know about the medications that they are taking.

Sorry. I meant:

"Flexeril (cyclobenzaprine) is structurally related to an older family of antidepressants called tricyclics, which also works on the serotonin SYSTEM."

Wow finally the RIGHT answer. This is what I have learned when I researched the two drugs. You must be in the medical field......you nailed it!!

My doctor prescribed both (at the same time) for me. I'm not saying it's safe but it's true.

NO absolutely do not do this!

It’s true. I suffered a level three concussion on January 8 and was prescribed Flexeril 10 mg and tramadol and was told I could take them both together in addition to taking butalbital with the cedar medicine for my migraines! I have more common sense than to mix drugs so I really only take the butalbital with the Seda medicine for my headaches because I need that the most. If I have to take something for my back pain and neck pain, I will not take my migraine medication and I will take a Flexeril if necessary or a tramadol but never would I mix them Together despite with any id**t doctor tells me. I don’t think these people realize the effects of these drugs. I can’t take any drugs at all because they all make me wig out either stop breathing or get palpitations. I would take one at a time and narrow it down to what you really need. Either way, whatever you take is going to make you relax so you should be able to try to get some sleep. Good luck.

I accidentally took tramadol 50 mg then half hour later cyclobenzaprine 10mg not thinking after a rather stressful day should I be worried