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What antidepressant DOES NOT aggravate restless leg syndrome?

By farmerswife | 29 posts, last post
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Guest

You are very fortunate. After tons of research about antidepressants, I finally suggested Trazodone to my physician. Tried it, and it only took one night for me to discover that even this still triggered the worst RLS ever! I guess some of us must, in fact, choose marginal sleep over relief from depression. I am very happy for you that Trazodone works for you!
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Guest

How much klonopin do you take?
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Guest

Me too,i take Clonazepam for RLS but suffer from anxiety and depression,if i go on antidepressants my RLS gets worse and goes into my arms and legs,surely there MUST be an antidepressant that does not make RLS worse ? !!!
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Guest

Hi there, I know the feeling. I’ve been on Cymbalta for almost 6 months and began having RLS 3 months in. Amazingly enough what helped me get rid of RLS was cutting out caffeine completely. I only drink decaf now and sleep like a baby again.
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Guest

My sleep neurologist prescribes carbidopa levadopa for my RLS and it's been the most effective treatment.
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Guest

You can try the Health Food Store. They have a homeopathic that helps me.
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Guest

My RLS went into overload after getting shingles and even the smallest dosage of Amitriptyline would bring it on. I switched to Trazodone and it eliminated it almost completely.
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Guest

Trazodone makes me have rls, I am taking Zoloft for ptsd and now it is starting to make me have rls also. I have called it my miracle drug. I don't know what will happen if I have to stop taking it...………
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Guest

i'm a lifelong restless legs sufferer - sleep and plane travel, even going to the movies or theater is almost impossible. Trazadone made it a lot worse. I'm now starting Cymbalta and that too seems to be making it worse. However, my daughter who has RLS too has been taking trazadone and seems fine on it. Unfortunately, the trazadone gave her nightmares/ middle of the night panic attacks, which her doctor said actually means it is working. None of these are clean or simple, it is so individual.
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Guest

Vaccines cause autism. Carpe Diem.
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Guest

I stopped my cymbalta 120 mg cold all at once a few days later i could sleep without anything for my RLS But i'm an emotional mess i'v had a stroke in my basal Ganglia so not a lot of control of stress & anxiety without meds have to start over i guess.
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Guest

They don't, no medical evidence (any that did exist has been rejected), and you're a wrong for suggesting so. Try being helpful instead of spreading misinformation.

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Guest

Wellbutrin does not cause restless leg. Tramadol is a miracle cure for restless leg.. I've tried a number of drugs specific to RLS and it works until it explodes into worse RLS. Tramadol works as an antidepressant and alieviates RLS. Clonazepam helps. My problem is the limitation on the "controlled substance" It doesn't make you high it doesn't have any side effects and I've been taking it for about 5 years. I'm under extraordinary stress which triggers RLS apparently and as a result have had to take more to overcome the symptoms which causes me to stress over running out. It has saved my life Wellbutrin and Tramadol. I'm going to run short so I'm taking extra Wellbutrin and Clonazepam and hopefully get to my next script. The Tramadol is addictive and it was well aware of it and willing to deal with it. I told my Dr if it had to be a drug addict the rest of my life the so be it. RLS is extreme for me and I cannot will not tolerate it. There is a difference between using a drug that works in whatever amount it takes verses taking/abusing the drug to get high. Tramadol doesn't make me high. But you can feel the anxiety dissipate and the RLS subside in short order.
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Guest

I've tried Trazodone and I believe it made my RLS a bit worse. But not crazy bad. It's worth trying
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Health Hero
1626 posts

Levar85

Hi, guys.

Here is an answer from one of our medical staff.

Restless leg syndrome (RLS) is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. Some antidepressants can exacerbate RLS symptoms, while others may be less likely to cause problems.

Some antidepressants that have been reported to aggravate RLS symptoms include selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac), sertraline (Zoloft), and paroxetine (Paxil), as well as tricyclic antidepressants such as amitriptyline (Elavil) and nortriptyline (Pamelor).

Bupropion (Wellbutrin) is an antidepressant that may be less likely to aggravate RLS symptoms, although it can sometimes cause its own set of side effects. Another option is mirtazapine (Remeron), which has been shown to improve RLS symptoms in some people.

Good luck!

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