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Just smoking weed once probably won't interfere with Wellbutrin but someone said it can build up in your body and cause seizures.
Weed however DOES interact with SSRI anti-depressents. Be carefull when your on those.
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Wellbutrin(bupropion) lowers your threshold for seizures, which your doctor should have told you when you went on it. when drinking that lowers your threshold even more, so even if you've never had a seizure before you are more susceptible to having one while on wellbutrin(bupropion).
I've had one grand mal seizure 10 years ago and my doctor was hesitant to put me on wellbutrin for this reason. even though its been 10 years it won't matter because my threshold for having a seizure is decreased while taking this medication. if you have had any tachycardia(racing heart/rapid pulse) it may be an interaction from other medications, even over the counter ones.
I have smoked weed regularly for about a year now and only had one or two panic attacks, which i am susceptible to anyways. The act of smoking weed will raise your heart rate, but in conjunction with many other medications gives you a risk of an even higher pulse rate. I've been on wellbutrin and doxepin for over 3 months and haven't had any interactions with anything until recently. I was also put on an anti-seizure medication for a short time but the side effects were too much to handle. I was also put on prednisone for a sinus infection not too long ago. One night I smoked after taking wellbutrin during the day(two doses of 150mg each) and doxepin 50mg(which i take in low dose for headaches) later that night and my resting heart rate when up to 200bpm. My blood pressure also sky rocketed to 150/100, mind you I am 23years old and have have very low blood pressure in the past, to the point i had to take medication to up my blood pressure. This reaction has happened about 4 times in the last month. It is accompanied by severe light headedness and chest pain(most likely from the rapid heart rate). I caution anyone that is going to mix much with wellbutrin especially if you are already susceptible to seizures, vascular migraines or have a regularly high resting pulse rate. If you're going to smoke, make sure you do it in moderation first to see how your body will react and gradually build up a tolerance. Don't just go off and smoke a few blunts to your dome.
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Its all about tolerance, get your system used to the bupropion first. I do recommend though if you smoke marijuana to stop taking your anti depressants as you will likely become addicted to both making the bupoprion useless by itself if you quit smoking weed.
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I use Wellbutrin to treat ADD though and not depression. I've tried life without drugs, with just pot, with pot AND wellbutrin, and with just Wellbutrin. Best results...Wellbutrin with no pot. Became more productive, got married, felt great almost every day. Changed my life. Just better all around.
I am a pot proponent, but if you can quit, do it. It ain't helping MOST people I think.
My 2 cents.
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I was talking welbutrin as well and when smoked weed i had sensory seizures, very scary includes hallucinations hearing things (unpleasant things), smelling and tasting went weird lasting over 2 hours, some muscles were even seizing indicating i was very close to having a full body seizure.
Be cautious!!!!
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Whoever told you it takes 3 months to clear THC from your system has a terrible metabolism. I know people who can fully detox from heavy use in under a week.
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