My wife is receiving ondasetron to relieve symptoms of nausea and vomiting. She is going to chemotherapy because of the advanced cancer that she has. Chemotherapy provokes nausea in her. Doctors say that it is common. Now they want to change medication. They say that Palonosetron is better and that it is different from the current first generation 5-HT3 agents. How different he is?
I am sure that doctors know what to do for the best outcome. Palonosetron is different from older types of 5-HT3 agents. It is new medication. It is first medication for CINV in decade. Also it has 100-fold greater binding affinity for the type 3 serotonin receptor. Its half life is longer then ondacetron and it lasts around 40 hours.