methadone has a half life of 110 hours. so half will be gone in 110 hours. half of that will be gone in 110 hours. so if you take 100mg in a few days it will be 50mg...a few days later it will be 25. this is only the biological half life. the clinical life of the medication (how long it "works" on you) is about 6-9 hours. it has teh longest half life of opiates.
taking a substantial dose would definately show up in a drug test one week later because of this fact.
many people have died from mixing methadone with other opiates , maybe because of the confusion about suboxone and thinking that they are similar when they are not.
methadone should NEVER be mixed with alcohol. you should use EXTREME CAUTION when mixing with another painkiller ONLY WHEN DOCTOR DIRECTS YOU TO. TELL ALL DOCTORS and PHARMACISTS ALL OVER THE COUNTER MEDS AND VITAMINS AND HERBAL REMEDIES USED because they could be DANGEROUS WHEN MIXED. even ANTIDEPRESSANTS can be DANGEROUS WHEN MIXED. make sure your doctor knows everything you take and follow all directions. tell your doctor if ANYTHING SEEMS WEIRD TO YOU when taking this med. it is REALLY EASY to overdose.
taking a substantial dose would definately show up in a drug test one week later because of this fact.
many people have died from mixing methadone with other opiates , maybe because of the confusion about suboxone and thinking that they are similar when they are not.
methadone should NEVER be mixed with alcohol. you should use EXTREME CAUTION when mixing with another painkiller ONLY WHEN DOCTOR DIRECTS YOU TO. TELL ALL DOCTORS and PHARMACISTS ALL OVER THE COUNTER MEDS AND VITAMINS AND HERBAL REMEDIES USED because they could be DANGEROUS WHEN MIXED. even ANTIDEPRESSANTS can be DANGEROUS WHEN MIXED. make sure your doctor knows everything you take and follow all directions. tell your doctor if ANYTHING SEEMS WEIRD TO YOU when taking this med. it is REALLY EASY to overdose.
I dont care what anyone says Ive been taking oxys and methadone for about 8 years now and i know FOR A FACT methadone blocks oxycontin effects I dont care what anyone says i know from personal experience METHADONE DOES BLOCK OXYS. When i started taking methadone my oxy 80mgs wouldnt do a thing. I would only have to take a half, and when i took methadone i took 2 80s and didnt feel a thing. Methadone helped me get off oxys because they no longer did anything while on methadone. Dont listen to the people who say it wont block opiates because it will. I've personally tested it for a year strait. Personal experience is knowing, not what some Dr thinks or what someone has read in a book.
Actually, I don't know it all, but do know alot :-| . I just want to add that methadone is NOT a blocker, which means it is an anti-antagonist. What it is not, is an antagonist, which means it would block, but it is the former, which means it is the preferred molecule that fits in your receptors in your brain like a puzzle. The synthetic meth, of which it is, is when molecules are manipulated through additions and/or reductions in chemical reactions. The reason they give meth to people that are heroin addicted is because 1) it is legal form of (ha, ha, what a joke) of heroin. What it doesn't do is give you the intense high that heroin gives, but it is much longer acting. Meth is a bigger molecule and your brain receptors "desire" it more then the heroin. Let's say you have a 1000 receptors in your brain, and 1000 molecules of meth are released in your brain, along with 100 molecules of heroin. Well, your brain receptors PREFER the meth molecule because it is more a perfect fit for the receptor. Thus all 1000 will take up on on these receptors, rendering the 100 of heroin ineffective. It will just float around but will not have an effect. Now, let say you took the 100 molecules of heroin first without any exposure to meth yet. All 100 will attached to these receptors. Now, if you take meth within the 4 hour half-life of herion, the meth molecules with STRIP the heroin molecules off of your receptors, and be replaced by meth. molecules. Meth and Oxy can be combined as long as the meth dosage is low enough, and the oxy dose is high enough. The combined effect has a synergistic effect on pain relief. Meaning that they both become more effective for pain just because they both are attached to receptors in the brain at the same time. But, remember, if you take a meth that is high enough in dosage, it will STRIP all oxy molecules of the receptor sites, and render useless. This is what ANTI-ANTAGONIST narcotics do. Subutex is also an ANTI-ANTAGONIST.
Naxalone, and Suboxone are the only ANTAGONIST that I know of. Okay, the former is used to bring people who O.D. on Heroin back to "instant" life. It NOT, only strips of opiates, but it takes it's place, and can cause instant withdrawal, but can save someone's life. Also, naxalone is used for people that fear that they will go back on opiates. So, that when they do try an opiate, like heroin, the heroin will be ineffective because the naxalone will BLOCK the receptors from uptaking any of the molecules because the molecules from the naxalone is already there. Now, suboxone is what I think is a "partial-antagonist," because it does BLOCK opiates, but at the sametime it's molecular structure can keep ONE from withdrawing. It makes you wonder why methadone is still legal for treating heroin addiction. I also know that if you only take suboxone for only a week after you quit heroin that you will experience NO withdrawal symptoms, but you may experience cravings, and that is why some stay on it much longer as a maintainence drug. It's the "rich" man's drug, UNFORTUNATELY!! The same goes for subutex. The only difference with Subutex is that it is NOT an antagonist. You can use it to experience NO withdrawal symptoms, without fearing it blocking you from opiates. In otherwords, with the latter you can go out and get juiced up on herion for a month, and take these pills when you run out and you will not withdrawal. Also, heroin will work while taking these pills but wont be as effective because subutex is "preferrred" by your receptors. Subutex is also a "rich" man's drug >;) . It cost over $500 for month's supply and you do NOT have to go to a clinic every f*****g morning >:( at the crack of dawn o.O to get it. Subutex doesn't make you high :-( , but methadone is more effective for that ;-) . Also, if you go off of subutex and it is an opiod, the withdrawal symptoms if any at all are suppose to be minor XD . This I can not attest for. I only know that if you take it for a week after quiting heroin, you will feel NO withdrawal symptoms whatsoever ! ! ! :-D 8) . Continued use into a indefinite period might last longer. Not sure.
Hope this helps some people along with the other info. that was really good. Again, Meth does NOT block opiates!! It just competes with other opiates at the receptors and ALWAYS wins! So, the "other" opiates/heroin/oxy's,etc. float around in brain space and are rendered totally ineffective or at least almost totally ineffective. That's it. If I am wrong about anything, bring it on here in a reply post. LOL.
Good luck to all.
The sh*t should be legal anyway!!! LOL. XD
Naxalone, and Suboxone are the only ANTAGONIST that I know of. Okay, the former is used to bring people who O.D. on Heroin back to "instant" life. It NOT, only strips of opiates, but it takes it's place, and can cause instant withdrawal, but can save someone's life. Also, naxalone is used for people that fear that they will go back on opiates. So, that when they do try an opiate, like heroin, the heroin will be ineffective because the naxalone will BLOCK the receptors from uptaking any of the molecules because the molecules from the naxalone is already there. Now, suboxone is what I think is a "partial-antagonist," because it does BLOCK opiates, but at the sametime it's molecular structure can keep ONE from withdrawing. It makes you wonder why methadone is still legal for treating heroin addiction. I also know that if you only take suboxone for only a week after you quit heroin that you will experience NO withdrawal symptoms, but you may experience cravings, and that is why some stay on it much longer as a maintainence drug. It's the "rich" man's drug, UNFORTUNATELY!! The same goes for subutex. The only difference with Subutex is that it is NOT an antagonist. You can use it to experience NO withdrawal symptoms, without fearing it blocking you from opiates. In otherwords, with the latter you can go out and get juiced up on herion for a month, and take these pills when you run out and you will not withdrawal. Also, heroin will work while taking these pills but wont be as effective because subutex is "preferrred" by your receptors. Subutex is also a "rich" man's drug >;) . It cost over $500 for month's supply and you do NOT have to go to a clinic every f*****g morning >:( at the crack of dawn o.O to get it. Subutex doesn't make you high :-( , but methadone is more effective for that ;-) . Also, if you go off of subutex and it is an opiod, the withdrawal symptoms if any at all are suppose to be minor XD . This I can not attest for. I only know that if you take it for a week after quiting heroin, you will feel NO withdrawal symptoms whatsoever ! ! ! :-D 8) . Continued use into a indefinite period might last longer. Not sure.
Hope this helps some people along with the other info. that was really good. Again, Meth does NOT block opiates!! It just competes with other opiates at the receptors and ALWAYS wins! So, the "other" opiates/heroin/oxy's,etc. float around in brain space and are rendered totally ineffective or at least almost totally ineffective. That's it. If I am wrong about anything, bring it on here in a reply post. LOL.
Good luck to all.
The sh*t should be legal anyway!!! LOL. XD
To the person who thinks that methdone is an antogonist it is not clearly you are an id**t. No narcotic cancels the other, the only thing that you hav eto worry about is stacking and drug interaction. It is clear to me that the person that thinks that methodne cancels oxycontin clearly needs to contact thier doctor and not their drug dealer.
Methadone becomes a blocker at 70 ml dose or higher,but any dose under 70 will not block the effects of other opiode narcotic painkillers,or heroin
I wish people would be more careful when making UNQUALIFIED statements about, narcotics, opiods, and other various pain medicines. People who speak from personal experience are fine & usually most helpful, but when people who claim to be "experts" try to advise others they often advise incorrectly. I realize they are just trying to help, but please try to make a precursory statement as to where your expertise truly originates
I disagree with methadone being used in long term pain management. I have been going to a methadone clinic for 2 years. The pain relief from methadone ended for me about 2 months after i started the clinic. Kentucky angers me when i see my family elder's suffering in severe pain because doctors are afraid of losing their licence due to the dea. it's sickening. And it even bothers me more that i have to drive 3 hours a day going to a methadone clinic in Knoxville, TN from Pineville Kentucky. You must be 25 years old before you can be accepted into methadone clinics in Kentucky. I guess they want to let the youth destroy there live's before they letting them get help that really works. I though Kentucky had a drug problem? No they have a legislative problem.
I started a methadone maintenance treatment center to help with my pain from a broken neck, hips, and ribs when every pain clinic I went to said I was too young for treatment, to find some other way to deal with my pain I had been going to a methadone clinic in eastern KY for almost 3 yrs and it is true that methadone blocks out other opiates I think that people should know what they're talking about before posting comments like this 8-|
Were do you people get your information?? And word of advice stay away from Methadone!! Its poison!!! Ween off with oxy's don't go on the methadone, I am going through hell coming off this c**p its been 5 days and I feel like Im dying!!
I have to agree with the guy in the post before mine. Where do you people get your info??? Escespecially this post i quoted. If you are saying that being on 120mg of methadone has worked out great rather than oxy's with less side effects thasn methadone and, with methadone they weene you all the way down. lol. Sorry just so many confused people on this forum. If you are doing five 80mg oxycontin a day, you cvan come off that in 24hrs, star suboxone and not go throuhg one single withdrawal, except the 24 hrs until the drug clears your body so the suboxone can eliminate withdrawal, and you come off suboxone as fast or slow slow as you want and its no where near the addictive properties and all the problems the devils drug (methadone) offers. You see. methadone has a half life of 36 hours, and it climbs as u go up in dose until it can take 3 weeks before you take your last dose out. Thats 3 weeks of painful detox worse than heroin and oxys put together. I have come off oxys and herion so many times its laughable, then they told me methadone will save me, currently at 100mg, using no methadone and I am back on oxys and herion for a week or two to cut down on that stupid drug. So i used til my tolerance was equal to 50mg of dome. I did what i could not do there in 4 months in 2 weeks off oxys and heroin. So back at 50mg until I reach 30mg of dome, and detoxing from 50mg to 30mg, is so hard and the most pain. You see methadone is 3 to 5 times harder to get off than heroin, and ten times harder than oxys to stop, hence methadone cflinics are state funded programs, so the state loves you guys cuz you will be on for life and this drug will ruin your life faster than herion or oxycontin. As soon as a reach 30mg it takes 5 to 7 days to get 30mg out, so instead of going through 3 weeks of hell, am jumping off methadone, and back on oxys for five days than suboxone. Ten year opiate addict here, aka chronic pain patient, all the same. Bottom line you can get of oxycontin or heriopn or any percocet, norco, just by going 5 days and your feeling better, for chronic pain or addicts, or those who dont want to withdrawal to the point of dying, stay on your oxycontin, if you want off it takes 24hrs, than suboxone, same as herion or morphine, methadone is the only drug that takes a month to withdrawal from and its worse than oxycontin, heroin, and xanax withdrawal, cuz i've done all three cold turkey, except xanax i went inpatenient because you can siezure if you stop suddenly. So best of luck with the methadome, you will be life long dosing if you dont take back your life now. Oxycontin works wonderful if not abused, any doctor who wont prescribe it, but gives out 10mg methadome, ought to be turned in to the AMA. No doc should be able to prescriube methadome, it should only be at clinics and for herion addicts only who want to stay on maintenance (for life). So read up a bit before you slowly what the doc gives you, i was once givewn methadone to, and a year later i am finally gettin my life back my movin my dose down to 30mg and back to oxycontin for 5 days than 24 hours clean than suboxone, than done in a few weeks with limited pain. Thats how you do it
The person that said "20mg of Oxycontin can be replaced by 10mg of Methadone" hasn't got a clue, I know I've taken both and let me tell you straight Methadone doesn't even come close to providing the same pain relief. I was on oxy 20's for severe back pain and then the Doctor got all nervous about it b/c of the damn government (and a nosy pharmacist) so he withdrew the medication...leaving me screwed, so I went to the methadone clinic and eventually had the dose raised to 160ml/day..and guess what ..the back pain's still there!
I have been taking endocet for over a a couple years now I get about 240 a month from a pain clinic. But I had to change pain clinics because the one I was going to was about a 2 hour drive. I just started the new one and the doctor there started me on methadone 10mg taking one every 8 hours. Is this alot less than I've been taking. Will I have withdrawls going off endocet and going on 10mg methadone, I was taking 6 endocets a say.
I'm on 10mg methadone t.i.d. and 10/325mg Norco t.i.d. This has been my regimen for years after a bad reaction to Tramadol (which is super addictive). This helps my pain a lot - the methadone gives a baseline painkilling dose with breakthrough pain being handled by the Norco - good combo.
Acutally you can take Oxycodone with Methadone... Methadone only blocks the high feeling from other opiates,
The Oxycodone will still help with pain but the methadone blocks the high you would get if not on Methadone. I
also believe Methadone is a great drug! I was addicted to Oxycotin(oxycodone Time Release), I was talking
around 320mg to 400mg of Oxy a day. I was very skinny and always out of it. Then I got on methadone and
I started to gain weight and keep a job. Also for addicts methadone is a good idea because while on Methadone
trying to get high off other opiates will not work because of the blocking effects of the drug. My girlfriend and I went
on vacation to New York and they wouldn't fill our scripts of 5mg Oxycodone & 20mg Oxycotin because of the law there.
They said we needed a certain certificate to fill the script. We had to drive to Pa to get our medicine. Also if depends
on the person but Methadone is a hell of alot harder to come off of than Oxycodone. A Oxycotin dose usally last for about
8 hours where Methadone last 24 hours before you start feeling some withdraw symptoms. You can gradually lower
your dose but to be comfortable you'll have to lower you mg's a certain way. (Like 5mg every 3-4 weeks). Everyone
is different. I know a few folks who came of methadone cold turkey with hardly no problems at all and they were on
120mg of Methadone.
The Oxycodone will still help with pain but the methadone blocks the high you would get if not on Methadone. I
also believe Methadone is a great drug! I was addicted to Oxycotin(oxycodone Time Release), I was talking
around 320mg to 400mg of Oxy a day. I was very skinny and always out of it. Then I got on methadone and
I started to gain weight and keep a job. Also for addicts methadone is a good idea because while on Methadone
trying to get high off other opiates will not work because of the blocking effects of the drug. My girlfriend and I went
on vacation to New York and they wouldn't fill our scripts of 5mg Oxycodone & 20mg Oxycotin because of the law there.
They said we needed a certain certificate to fill the script. We had to drive to Pa to get our medicine. Also if depends
on the person but Methadone is a hell of alot harder to come off of than Oxycodone. A Oxycotin dose usally last for about
8 hours where Methadone last 24 hours before you start feeling some withdraw symptoms. You can gradually lower
your dose but to be comfortable you'll have to lower you mg's a certain way. (Like 5mg every 3-4 weeks). Everyone
is different. I know a few folks who came of methadone cold turkey with hardly no problems at all and they were on
120mg of Methadone.
I am given per month scripts for 220 roxycodones @ 30 mg, 240 methadone @ 10 mg and 90 xanex @ 5 mg. these meds needless to say are a pretty big part of my life as I have been on methadone for over 10 yrs and the secondary is switched, I was taking percocet 10/325 at 180 per mnth b4 we swtched to the roxycodone. The methadone is extended release. They just prescribed the neurontin with a starting dose of 100 mg with 400 mg per day dosing to start and has intentions of going to 300 mg 4 times per day. I just was not sure on what neurontin is and is it safe to use with the rest