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There's no shortage of scientific studies into the effect marijuana has on the immune system, but studies into the possibility of being immune to cannabis are nearly completely non-existent. There's one that shows that high levels of the inactive precursor to steroid hormones, pregnenolone, messes with the function of THC — in lab rats, that is. That's about it. 

Yet, plenty of people "complain" that they're simply not getting high after using weed. Why could this be? Is it some genetic thing? Is it the quality of the weed? Folks who seem to be immune to marijuana want answers, and unfortunately, science isn't there to help you out, unless you think your body is somehow producing lots and lots of pregnenolone, which the above study was researching as a possible treatment for cannabis addiction, naturally. 

There are, however, some possible answers. To get them, we'll have to turn to a combination of science and common sense. (At SteadyHealth, we obviously have a global audience, and some of our readers will live in jurisdictions where marijuana use is legal. We're not encouraging to break your local laws.)

New To Cannabis?

Plenty of former first-time cannabis users, who usually try weed in the form of smoking, note that they didn't get high during their initiation into marijuana use. Regular users speculate that this may be because it takes the body's cannabinoid receptors a while to "wake up". If you didn't get high the first time, you may have better luck later on. 

Another possibility is that, having read and heard about the effects of weed, you're simply expecting more than you're going to get. This is almost certainly the case for those people who say they're "not high" but experience some sort of effect after smoking weed, such as heightened perception, relaxation, or feeling slightly more mellow. You're high — it just isn't what you thought it would be. 

Some people may also simply be inhaling incorrectly, and thereby miss out on the effects of marijuana. This applies to folks who say they get high after eating a cannabis brownie, while smoking does nothing for them. 

Experienced Cannabis Users

"Heavy marijuana smokers," one study found, "show less cognitive impairment following acute marijuana administration." Experienced cannabis users were able to perform complex cognitive tasks with no problem. Were they also feeling less high, or not high at all? Maybe it's a simple matter of tolerance. Getting high is still possible if you continue smoking, but if this is you, the universe may be sending you a message that it's time for a time out. 

On the other hand, unless you really know your stuff or are growing your own, you may not really know what you are getting, either. It is possible you may have been sent home with a batch of marijuana that's a high CBD (cannabidiol) and low THC strain — hence you might experience mild analgesic and anxiety relieving effects, and not much else. If this is so, getting marijuana from a different source may solve the "problem".

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