In the liver, the enzyme alcohol dehydrogenase oxidizes ethanol into acetaldehyde, which is then further oxidized into harmless acetic acid by acetaldehyde dehydrogenase. These two oxidation reactions are coupled with the reduction of NAD+ to NADH. In the brain, alcohol dehydrogenase has a minor role in the oxidation of ethanol to acetaldehyde. Instead, the enzyme catalase primarily oxidizes ethanol to acetaldehyde.
Most people of East Asian descent have a mutation in their alcohol dehydrogenase gene that makes this enzyme unusually effective at converting ethanol to acetaldehyde, and about half of such people also have a form of acetaldehyde dehydrogenase that is less effective at converting acetaldehyde to acetic acid. This combination causes them to suffer from alcohol flush reaction, in which acetaldehyde accumulates after drinking, leading to immediate and severe hangover symptoms. These people are therefore less likely to become alcoholics.
The drug disulfiram (Antabuse) prevents the oxidation of acetaldehyde to acetic acid, and it has the same unpleasant effect on drinkers. Antabuse is used as a deterrent for alcoholics who wish to stay sober.
READ THIS ARTICLE ON HODGKINS LYMPHNOMA. PAIN WITH ALCOHOL IS AN EARLY WARNING SIGN.
Alcohol dehydrated you, that'by why you get pain in the arm and legs. just drink more water and a gatoraid before and after drinking and most of you will be fine. Works everytime for me and I'm a healthy 21 year old.
Ooouuucch! Definitely drank a lot more than usual last night and woke up entirely too early because of the pain. It is in my hips more than anything. I am worried because I did fall down last night. Ha! Bruise on my butt. I am hoping it's not from the fall though.. Anyway, I can kind of feel it in my lower back and knees too, so I am assuming it's from the alcohol.. Can this really last up to 24 hours? and HOW DO YOU MAKE IT GO AWAY?
Leg problem n trust me I can wake up the next day feeling good but hard liquor like rum, vodka just hard core makes me paralysis... Beer also just sore me up but seriously only red wine helps... Weird but true
I have a similar problem. It occurs after a night of heavy binge drinking, usually hard liquor. I get a dull aching pain in my bones, but only in my legs. It helps to get up and walk about, but I have this other symptom which results in my body locking up. It usually starts in the legs, but when I straighten my legs out they lock up. This wouldn't be such a problem if I didn't live on the 3rd floor. My arms are usually the next to go, they lock up at a ninety degree angle. After these goes my spine; if I hunch over to tie my shoe or something, it locks up. These are just the main problems I have related to a hangover, I have many more, but I feel like I'd be splitting hairs. Please Help!