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Okay, common sense answer here, people. Here's three easy-to-follow steps to solve this problem as rapidly and safely as you can.
  1. Don't panic. The last thing your body needs is the additional stress. If it is a stress-related issue, you're only going to make it worse. If it isn't, you're not going to help it by worrying.
  2. See a doctor you trust. If you don't have a doctor you trust, seek a recommendation from a friend you trust. Present your symptoms and let the doctor do the analysis. If a general physician cannot help you, seek a specialist.
  3. Until you find a solution, if you are embarrassed about the missing patches of hair, shave the rest of your legs, arms, etc. to match or feel free to cover up. Once you've done that, don't worry about it. Humanity has not yet been equipped with x-ray vision (to my knowledge), and if anyone did have x-ray vision, they have far more interesting things to look at than bald patches on your legs.
I should stress how important it is to not panic. While momentary panic is a perfectly natural reaction, long-term panic or worry can cause unnecessary stress that has its own downsides. Find a way to relax yourself about this problem. (e.g. talk it off with someone who will listen, do something to take your mind off it) As radical an idea as this is, you should not spend hours online researching your problem in an attempt to diagnose before your doctor so much as sees it. Unless you yourself are a medical practitioner, you have neither the tools nor the education to which your doctor has access. It's fine to do a little research of your own, but without the proper knowledge and testing equipment, there's no way for you to diagnose something as multi-causal as hair-loss.

Now, I just sit and wait to see if I get kicked off or flamed for suggesting such heresies. 
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Have had the same thing for a few years. I'm 29 and it started when I was 23. Its definitely genetic as both my father and grandfather both have the same issue. Besides genetics, I think it also has to do with socks as I started wearing dress socks for work around 22. My dad said it started when he was around 20 and he started wearing high socks for work around 18, and my grandfather says it started when he was in high school and wore high socks through most of his school days
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Same symptoms as most. Hairless patches on front of both ankles. I'm 46 but I don't know how long I've had it. Like many of the contributors, I am physically very active, running, cycling and swimming roughly every other day.

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I read on a homeopathic site it could be a sign of adrenaline fatigue due to consumption of mass amounts of sugar and caffeine. Other side effects were sleeping less at night and hollowed cheeks.
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I posted last year... cause i lost patches of leg hair.

One year later now, My leg hair grew back, so you guys can take a rest...

There are a million reasons why you can loose leg hair. The worst being cancer, the least being just 'hairloss'.

The thing is that you freak out when something out of the ordinary happens. The truth is that it rarely anything serious.

Pain in your head can be a tumor, but most often its just head pain. Dont worry. kick back. Relax.

 

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Male, 34, North European decent. Ma calves started going bald some 5 years ago and now I almost have no hair symmetrically on the lateral side of me calves. Medial sides are hairy. I went through previous posts and the conclusion that can be made that this is a common genetic trait in a certain population of men (and women?). In general, symmetrical balding would seem like a result of abrasion, but it seems that there is no correlation between the time of wearing tight clothes and progressive leg hair loss. In some circumstances, though, there can be pathological background, intuitively, I would expect it to be more common in patchy-type hair loss. However patchy-type could also be genetic. Further research is needed :-)

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i also lost mosr of the hair on my legs due to a serious illness (i had a bad infection of the asophcis?) i lost 4 stone in three months, i collapsed and was taken in to hospital. i was then put on ensure plus drinks and would you believe it my weight started to come back, my arms and legs have all the hair back and more hope this helps.

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Thank you to all who took the time to provide thoughtful and helpful responses.  I was so relieved to find this thread.

I am a 25/M, generally healthy.  Over the last few months, I started noticing this same issue.  At first, I only noticed it on the top/inside of my wrist.  The hair in the area was sparce and stubble-like.  Looking almost like I had singed it with a lighter.  After noticing the same issue on my legs (started on just my calf, now extends down the outside of legs) I began to worry.

I've read so many different things, its hard to know what to think.  The only accompanying symptom mentioned that I have is swollen lymph nodes (for the past couple months, but I don't feel very sick or anything).

If anyone gets further info, please let me know.  I will follow-up after seeing a doctor next week.

 

Thanks,

Chris in VA

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I think there is a correlation between my lower leg hair loss and possible adrenalin fatigue.. an yeah i like my coffee too. I went to click on the links in your post but they disapeared. I would be very interested to know more about what you mentioned here or a link of sorts. been a bit concerned about it.

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With kind regards
Anthony

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My daughter says my loss of hair on my calves is because God wants me to become a Ladyboy.

Have them vaxed at let them shine she goes on.

Seriously I think the Testosterone is dropping...

You are supposed to walk after women rather than run...

 

 

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Before anything, check the material of the pants/socks you wear often. Polyester has been found to build up electrostatic energy in areas with more friction, and can cause hair loss to be symmetrical since you walk symmetrically. I noticed mine happened over the winter. I started wearing an extra layer to work. Turns out its 100% polyester. That material has been found to cause hair loss where cotton won't. Try not wearing polyester. Worth checking out if you haven't yet.
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surly this problem can be caused by bad circulation,i had this problem and my dr gave me medication to increase my circulation and hey presto all my hair on legs came back.
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could it be am always sitting on my bed with legs touching it playing my computer and starting to lose abit 

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I too suffer from the conditions mentioned and notice it happens to me in the winter.Wearing  shorts and no socks whenever I can in the summer the hair comes back. As soon as I can I get away to the sun and that generally restarts growth. I have started using for my sins the solarium and the rays do seem to hold it at bay. I am sure it is something to do with the cold weather (or perhaps central heating ) though no doctor I have spoken to can confirm this. I have had things from trouser trauma to alopecia suggested but no "medicine " has ever worked. Try the sun bed if you can and see what happens.

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bluedisc- Do you have this hairloss all the time?

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